Lecture 1  Microcytic Anemia o < 80 MCV  Sideroblastic anemia  Iron deficien

Lecture 1  Microcytic Anemia o < 80 MCV  Sideroblastic anemia  Iron deficiency  Anemia chronic inflammation  Iron-related Disorders o Iron deficiency anemia (IDA) o Anemia of chronic inflammatory disease (ACD) o Sideroblastic anemias  Hereditary sideroblastic anemia  Acquired sideroblastic anemia  Lead poisoning (porphyrias) o Hemochromatosis o Acute blood loss  Iron o 70% is in hemoglobin o 25% is in storage as ferritin and hemosiderin o Rest is in cytochromes, enzymes o Iron Function  Interacts reversibly with oxygen and functions in electron- transfer reactions (as ferrous) o The body is very efficient at recycling iron, daily need is only about 1 mg per day from loss through shedding of epithelial cells. o Menstruating women lose 2x as much o Too much iron in the body is toxic  Iron Metabolism o Depends on:  Iron intake & bioavailability  Ingestion - 90% iron salts, 10% heme iron from meat (but iron is more readily used from meat)  Absorption – heme iron (Hb & myoglobin in meat) is readily absorbed, iron in vegetables is mostly ferric, which is only absorbed if it is converted to ferrous (Fe++)  Need (iron losses)  Decreased iron stores and increased erythropoiesis increases absorption. o uploads/Litterature/ hematology-study-guide.pdf

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• Publié le Nov 11, 2021
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