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Hematology study guide Lecture Microcytic Anemia o MCV ? Sideroblastic anemia ? Iron de ?ciency ? Anemia chronic in ammation Iron-related Disorders o Iron de ?ciency anemia IDA o Anemia of chronic in ammatory disease ACD o Sideroblastic anemias ? Heredita

Lecture Microcytic Anemia o MCV ? Sideroblastic anemia ? Iron de ?ciency ? Anemia chronic in ammation Iron-related Disorders o Iron de ?ciency anemia IDA o Anemia of chronic in ammatory disease ACD o Sideroblastic anemias ? Hereditary sideroblastic anemia ? Acquired sideroblastic anemia ? Lead poisoning porphyrias o Hemochromatosis o Acute blood loss Iron o is in hemoglobin o is in storage as ferritin and hemosiderin o Rest is in cytochromes enzymes o Iron Function ? Interacts reversibly with oxygen and functions in electrontransfer reactions as ferrous o The body is very e ?cient at recycling iron daily need is only about mg per day from loss through shedding of epithelial cells o Menstruating women lose x as much o Too much iron in the body is toxic C ? Iron Metabolism o Depends on ? Iron intake bioavailability Ingestion - iron salts heme iron from meat but iron is more readily used from meat Absorption ?? heme iron Hb myoglobin in meat is readily absorbed iron in vegetables is mostly ferric which is only absorbed if it is converted to ferrous Fe ? Need iron losses Decreased iron stores and increased erythropoiesis increases absorption o C