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Faculté/Institut : Sciences exactes Département : Chimie 1- Identification du l

Faculté/Institut : Sciences exactes Département : Chimie 1- Identification du laboratoire/Unité de recherche إ سم المخبر Intitulé du Laboratoire Obtention de Substances Thérapeutiques Acronyme du labo LOST Adresse électronique lost@umc.edu.dz Site web ou URL www.lost.umc.edu.dz Année d’Agrément : 2002 Tel : 031811100 Fax : 031811100 2- Directeur du laboratoire/Unité de recherche Nom & Prénom Kabouche Zahia Grade : Prof Adresse Electronique zahiakabouche@gmail.com; zahiakabouche@umc.edu.dz Nombre Equipes : 4 Nbre Chercheurs : 36 Nbre Personnel soutien :1 3- Présentation du laboratoire Thèmes mis en œuvres : Thème 1: Synthèse catalytique de substances bioactives Thème 2: Séparation et identification des métabolites secondaires de plantes médicinales Algérienne et investigation de leur potentiel biologique (activités antioxydante, anticholinstérase, anticancer , anti- inflammatoire...) Thème 3: Plantes médicinales utilisées contre l'inflammation Thème 4: Drug Design basé sur POM (Petra Osiris Molinspiration) et sur d'autres logiciels plus performants pour la modélisation et l'étude de la relation structure-activité (antioxydante, anti- inflammatoire, etc...). Mots-Clés : Plantes médicinales, principes actifs, activités biologiques, inflammation, synthèse catalytique 4- Chefs d’équipes .Titre de l’Equipe1 Synthèse, isolement et drug design de molécules bioactives Nom - Chef d’équipe1 Kabouche Zahia Grade : Prof .Titre de l’Equipe2 Obtention de substances bioactives par voie naturelle Nom - Chef d’équipe2 Kabouche Ahmed Grade : Prof .Titre de l’Equipe3 Activités biologiques de plantes médicinales Algériennes Nom - Chef d’équipe3 Zerizer Sakina Grade : Prof .Titre de l’Equipe4 Etude phytochimique et évaluation du potentiel biologique de plantes médicinales algériennes Nom - Chef d’équipe4 Berrehal Djemaa Grade : MCA 5- Liste des publications : 1. H. Lakhal, A. Kabouche, Z. Kabouche, Flavonoids and antioxidant activity of Stachys olusatrum. Chemistry of Natural Compounds (2011), 46(6), 964-965. 2. A. Kabouche, Z. Kabouche, R. Touzani, C. Bruneau. Flavonoids from Centaurea sulphurea. Chemistry of Natural Coumpounds (2011), 45(6), 966-967. 3. I. L. Acebey-Castellon, L.Voutquenne-Nazabadioko, H. D. Thi Mai, N. Roseau, N. Boutaghane, D. Muhammad, E. Le Magrex Debar, S. C. Gangloff, M. Litaudon, T. Sevenet, Ng. Van Hung, C. Lavaud . Triterpenoid saponins from Symplocos lancifolia. Journal of Natural Products (2011), 74(2), 163–168. 4. K. Kaabeche-Djerafi, N. Bendjaballah-Lalaoui, S. Semra. Effect of medium capacity on the relationship between chemical heterogeneity and linearly adsorbed solute dispersion into fixed beds. Proceedings of World Academy of Science, Engineering and Technology (2011), 52, 686- 689. 5. O. Touafek, Z. Kabouche, I. Brouard, J. B. Bermejo. Flavonoids of Campanula alata DESF. and their antioxidant activity. Chemistry of Natural Compounds (2011), 45(6), 968-969. 6. R. Bencheraiet, H. Kherrab, A. Kabouche, Z. Kabouche, M. Jay. Flavonols and antioxidant activity of Ammi visnaga L. (Apiaceae). Records of Natural Products (2011), 5, 52-55. 7. N. Boutaghane, A. Kabouche, R. Touzani, Y. A. Maklad, Ai.El-Azzouny, C. Bruneau, Z. Kabouche. GC/MS Analysis and Analgesic Effect of the Essential Oil of Matricaria pubescens from Algeria. Natural Product Communications (2011), 6(2), 251-252. 8. S. Laggoune, A. Zeghib, A. Kabouche, Z. Kabouche, F. Leon, I. Brouard, J. Bermejo, C.A. Calliste, J.L. Duroux. Components and Antioxidant activity of the roots of the endemic species Stachys mialhesi de Noé. Records of Natural Products (2011), 3, 238-241. 9. T. Boudiar, C. Bensouici, J. Safaei-Ghomi, A. Kabouche, Z. Kabouche. GC/MS Analysis of Ammoides atlantica (Coss. et Dur.) Journal of Essential Oils Bearing Plants (2011), 14(2), 172- 174. 10. A. Labed, I. Labed, J. Safaei-Ghomi, A. Kabouche, Z. Kabouche. GC/MS Analysis of Oenanthe virgata Journal of Essential Oils Bearing Plants (2011), 14(4), 481-483. 11. S. Chibani, H. Berhail-Boudouda, A. Kabouche, T. Aburjai, Z. Kabouche, Analysis of the ²essential oil of Ferula communis L. from Constantine (Algeria). International Journal of Medicinal and Aromatic Plants (2011), 1(2), 41-44. 12. R. Bencheraiet, A. Kabouche, Z. Kabouche, M. Jay. Flavonols from Smyrnium olusatrum (Apiaceae). Chemistry of Natural Compounds (2011), 47, 813-814. 13. R. Bencheraiet, A. Kabouche, Z. Kabouche, M. Jay. Flavonols from Bupleurum plantagineum (Apiaceae). Chemistry of Natural Compounds (2011), 47, 814-815. 14. A. Khalfallah, A. Labed, A. Kabouche, Z. Semra, B. Ait Kaki, A. Kabouche, R. Touzani, Z. Kabouche. Antibacterial activity and chemical composition of essential oil of Ammi visnaga L. (Apiaceae) from Algeria. International Journal of Medicinal and Aromatic Plants (2011), 1(3), 302-305 15. A. Khalfallah, A. Karioti, D. Berrehal, A. Kabouche, M. Lucci, Z. Kabouche, A.R. Bilia . Flavonoid triglycosides from Astragalus armatus. 59th International Congress and Annual Meeting of the Society for Medicinal Plant Natural Product Research Antalya 09/11 (PG47). Planta Medica (2011), 77, 1229-1472. 16. T. Boudiar, I. labed, J. Safaei-Ghomi, A. Kabouche, Z. Kabouche. Analysis of the essential oil of Ruta chalepensis subsp. angustifolia from Algeria. Journal of Essential Oils Bearing Plants (2011), 14(6), 792-795. 17. R. Bencheraiet, A. Kabouche, Z. Kabouche, R. Touzani, M. Jay. Flavonol 3-O-glycosides from three Algerian Bupleurum species. Records of Natural Products (2012), 6, 174-175. 18. O. Touafek, Z. Kabouche, J. Boustie, C. Bruneau. A new long chain unsaturated ester and other constituents of Hypericum tomentosum (Clusiaceaer). Natural Product Communications (2012), 7(1), 63-64. 19. N. Benzeggouta, Z. Semra, Z. Kabouche. From ethnopharmacology to green chemistry “dawilou” a traditional herbal mixture. Pharmacophore (2012), 3(1), 76-80. 20. I Labed, S. Chibani, Z. Semra, A. Kabouche, T. Aburjai, R. Touzani, Z. Kabouche. Antibacterial activity and chemical composition of essential oil of Athamanta sicula L. (Apiaceae) from Algeria. E-Journal of Chemistry (2012), 9(2), 796-800. 21. T. Boudiar, Z. Sehli, B. Sandararaju, M. Achard, Z. Kabouche, H. Doucet, C. Bruneau. Isoquinoline derivatives viastepwise regioselective sp 2 and sp 3 C-H bond functionalizations. Journal of Organic Chemistry (2012), 77, 3677-3678. 22. A. Nacer, J Merza, Z. Kabouche, S. Rhouati, J. Boustie, P. Richomme. Sesquiterpenes lactones from Centaurea tougourensis. Biochemical Systematics and Ecology (2012), 43, 163-165. 23. S. Rekkab, H. Zarrok, R. Salghi, A. Zarrouk, Lh. Bazzi, B. Hammouti, Z. Kabouche, R. Touzani, M. Zougagh. Green corrosion inhibitor from essential oil of Eucalyptus globulus (Myrtaceae) for C38 steel in sulfuric acid Solution. Journal of Materials and Environmental Sciences (2012), 3(4), 613-627. 24. O. Gherboudj, N. Benkiki, E. Seguin, F. Tillequin, Z. Kabouche. Components of Matricaria pubescens (Desf.) Schultz (Asteraceae) from Algerian Septentrional Sahara. Chemistry of Natural Compounds (2012), 48(3), 470-471. 25. S. Bencharif-Betina, T. Miyamoto, C. Tanaka, Z. Kabouche, A-C. Mitaine-Offer, M.A. Lacailles Dubois. Two new triterpene saponins from Cyclamen africanum. 8th Joint Meeting of AFERP, ASP, GA, PSE and SIF, New York City, 07/2012 (PI298). Planta Medica (2012), 78 (11), 1027- 1310. 26. R. Bencheraiet, A. Kabouche, M. Jay, Z. Kabouche. Flavonoids of Phylospermum acteaefolium. Chemistry of Natural Compounds (2012), 48(3), 480-481. 27. A. Khalfallah, D. Berrehal, A. Kabouche, Z. Kabouche. Flavonoids of Centaurea omphalodes. Chemistry of Natural Compounds (2012), 48(3), 482-483. 28. H. Mokaddem-Daroui, O. Touafek, A. Kabouche, Z. Kabouche, C.A. Calliste, J.L. Duroux. Components and antioxidant activity of the polar extract of Chrysanthemum trifurcatum (Desf.) Batt. & Trab. Chemistry of Natural Compounds (2012), 48(3), 498-499. 29. C. Bensouici, A. Kabouche, Z. Kabouche. Flavonoids of Centaurea foucauldiana. Chemistry of Natural Compounds (2012), 48(3), 510-511. 30. D. Berrehal, A. Khalfallah, A. Kabouche, A. Karioti, A. Bilia, A.C. Goren, Z. Kabouche. Flavonol glycosides from Reseda arabica. Records of Natural Products (2012), 6(4), 368-370. 31. S. Bencharif-Betina, T. Miyamoto, C. Tanaka, Z. Kabouche, A-C. Mitaine-Offer, M.A. Lacailles Dubois. Two new triterpene saponins from Cyclamen africanum Boiss. & Reut. Helvetica Chimica Acta (2012), 95(9), 1573-1580. 32. S. Chibani, C. Bensouici, A. Kabouche, T. Aburjai, R. Touzani, Z. Kabouche. Analysis of the essential oil of aerial parts of Ferula lutea Poiret from Algeria. Journal of Essential Oils Bearing Plants (2012), 15(4), 682-685. 33. S. Chibani, C. Bensouici, A. Kabouche, Z. Kabouche, M. M. Al-Dabbas, T. Aburjai. Flavonoids and antioxidant activity of Santolina rosmarinifolia from Algeria. Chemistry of Natural Compounds (2012), 48(5), 877-878. 34. H. Kaddouri, M. Bouklah, S. Rekkab, R. Touzani, S.S. El-Deyab, B. Hammouti, A. Aouniti, Z. Kabouche. Thermodynamic chemical and electrochemical investigation of calixarene derivatives as corrosion inhibitor for mild steel in hydrochloric acid solution. International Journal of Electrochemical Sciences (2012), 7, 9003-9024. 35. S. Zerizer, K. S. Zaher N. Boutaghane, S. Laggoune, Z. Kabouche. Comparative effect of Chrysanthemum macrocarpum and Stachys mialhesi on the rats aorta exposed to homocysteine with B Vitamins. Scottish Journal of Arts, Social Sciences and Scientific Studies (2012), 6(1), 54- 64. 36. O. Touafek, M. Lahouel, E. Makhloufi, L. Benguedouar, J. Boustie, C. Bruneau, Z. Kabouche. Components and antioxidant activity of Hypericum tomentosum L. Journal of Biologically Active Products from Nature (2012), 2(3), 158-166. 37. H. Berhail Boudouda, A. Benmerache, S. Chibani, A. Kabouche, S. Abuhamdah, Z. Semra, Z. Kabouche. Antibacterial Activity and Chemical Composition of Essential Oils of Inula viscosa (L.) Ait. (Asteraceae) from Constantine, Algeria. Der Pharmacia Lettre (2012), 4(6), 1863-1867. 38. A. Benmerache, D. Berrehal, Khalfallah, A. Kabouche, Z. Semra, Z. Kabouche. Antioxidant, antibacterial activities and flavonoids of Reseda phyteuma L. Der Pharmacia Lettre (2012), 4(6), 1878-1882. 39. A. Benmebarek, S. Zerizer, S. Laggoune, Z. Kabouche. Immunostimulatory activity of Stachys mialhesi de Noé. Allergy, Asthma & Clinical Immunology (2013), 9:2 doi:10.1186/1710-1492-9-2, online January 2013. 40. H. Ghorab, A. Kabouche, Z. Semra, A. Ghannadi, E.B. Sajjadi, R. Touzani, Z. Kabouche. Biological activities and compositions of the essential oil of Thymus ciliatus from Algeria. Der Pharmacia Lettre (2013), 5(1), 28-32. 41. uploads/s3/ lost-chimie-kabouche-za.pdf