Remerciez-le!

Remerciez @Admin pour avoir partagé cet document gratuitement, de la manière la plus simple, en partageant sur les réseaux sociaux.

Cationorm guide Drugs Ther Perspect ?? DOI s - - - ADIS DRUG Q A CationormÒ cationic emulsion eye drops in dry eye disease a guide to its use Katherine A Lyseng-Williamson Published online June Ó Springer International Publishing Switzerland Abstract Cati

Drugs Ther Perspect ?? DOI s - - - ADIS DRUG Q A CationormÒ cationic emulsion eye drops in dry eye disease a guide to its use Katherine A Lyseng-Williamson Published online June Ó Springer International Publishing Switzerland Abstract CationormÒ is a unique preservative-free option for the treatment of the symptoms of dry eye that o ?ers some advantages over conventional arti ?cial tears The electrostatic interaction between the positively charged CationormÒ emulsion and the negatively charged cells on the ocular surface prolongs the residence time on the ocular surface Moreover as an oily emulsion CationormÒ augments all three layers of tear ?lm i e lipid layer aqueous coating and mucin layer thereby stabilizing the tear ?lm and providing bene ?cial moisturizing and lubricating e ?ects Overall the ef ?cacy and tolerability safety pro ?les of CationormÒ in treating mild to severe dry eye disease in clinical trials are similar to or better than those of other arti ?cial tears Adis evaluation of CationormÒ in dry eye disease Unique cationic emulsion that provides rapid and sustained relief of dry eye symptoms Supports all three layers of tear ?lm i e lipid layer aqueous coating and mucin layer thereby stabilizing the tear ?lm and moisturizing and lubricating the eye Equally or more e ?ective than comparator arti ?cial tears in treating mild to severe dry eye symptoms Does not cause blurred vision after application Very well tolerated Katherine A Lyseng-Williamson dtp adis com Springer Private Bag Mairangi Bay Auckland New Zealand What is the rationale for developing CationormÒ Dry eye disease is characterized by an inadequate quality or volume of tears leading to the chronic irritation and in ammation of the ocular surface ?? A relatively common condition dry eye disease a ?ects ?? of adults with an increased prevalence in older adults and in women and has a substantial e ?ect on visual function and health-related quality of life HR- QOL The two major subtypes of dry eye disease are aqueousde ?cient dry eye caused by the insuf ?cient production of tears by the lacrimal glands and evaporative dry eye caused by the excessive evaporation of tears Evaporative dry eye appears to be more common subtype and is commonly related to meibomian gland dysfunction MGD The two major subtypes of dry eye are not mutually exclusive and present with similar ocular symptoms such as dryness itching irritation foreign- body sensation and visual disturbance with some patients showing signs of damage to the ocular surface Some patients especially those who present with more severe symptoms early in the course of the disease will experience a worsening of ocular surface symptoms vision-related symptoms and HR-QOL over time Although a number of topical treatments for dry eye are available most are aqueous tear substitutes that provide lubrication hydration and protection but that do not improve the stability of the tear ?lm or prevent the excessive evaporation of tears There is a therapeutic need to develop new products to treat dry eye that stabilize